Information on Brian's conditions, medication and

notes from the Ozone Clinic

CIRRHOSIS

 

From Wikipedia, the free encyclopedia:

 

Cirrhosis is a condition in which the liver does not function properly due to long-term damage. This damage is characterized by the replacement of normal liver tissue by scar tissue. Typically, the disease develops slowly over months or years.  Early on, there are often no symptoms. As the disease worsens, a person may become tired, weak, itchy, have swelling in the lower legs, develop yellow skin, bruise easily, have fluid build-up in the abdomen, or develop spider-like blood vessels on the skin.  The fluid build-up in the abdomen may become spontaneously infected.  Other complications include hepatic encephalopathy, bleeding from dilated veins in the oesophagus or dilated stomach veins, and liver cancer. Hepatic encephalopathy results in confusion and may lead to unconsciousness.

PORTAL VEIN

From Wikipedia, the free encyclopedia:

The portal vein or hepatic portal vein is a blood vessel that carries blood from the gastrointestinal tract, gallbladder, pancreas, and spleen to the liver. This blood contains nutrients and toxins extracted from digested contents. Approximately 75% of total liver blood flow is through the portal vein, with the remainder coming from the hepatic artery proper. The blood leaves the liver to the heart in the hepatic veins.

The portal vein is not a true vein, because it conducts blood to capillary beds in the liver and not directly to the heart. It is a major component of the hepatic portal system, one of only two portal venous systems in the body – with the hypophyseal portal system being the other…

Increased blood pressure in the portal vein, called portal hypertension, is a major complication of liver disease, most commonly cirrhosis…

Clinical signs of portal hypertension include those of chronic liver disease: ascites,…

Ascites is the abnormal build-up of fluid in the abdomen. Technically, it is more than 25 mL of fluid in the peritoneal cavity.  Symptoms may include increased abdominal size, increased weight, abdominal discomfort, and shortness of breath. Complications can include spontaneous bacterial peritonitis.

In the developed world, the most common cause is liver cirrhosis. Other causes include cancer, heart failure, tuberculosis, pancreatitis, and blockage of the hepatic vein.  In cirrhosis, the underlying mechanism involves high blood pressure in the portal system and dysfunction of blood vessels.

Information taken from Package inserts:

 

LEXAMIL is indicated for the treatment of major depressive episodes.

Some of the side effects (there are too many to write here.)

Gastrointestinal disorders:

Common: Nausea, diarrhoea, constipation, decreased appetite, increased appetite.

Neuropsychiatric disorders:

Frequent: Seizures, paraesthesia, dizziness, insomnia, anxiety, restlessness, somnolence,

tremor, movement disorders, depersonalisation, abnormal dreams, panic attacks and nervousness.

 

PERIDOXINE.  Peridoxine is a vitamin B6 tablet.  The leaflet does not specify any side effects

 

ASPRIN:  The acetylsalicylic acid inhibits platelet aggregation

 

Side Effects and Special Precautions:

Upper and lower gastrointestinal tract disorders

 

GASTRIWIN:  Gastriwin Tablet is used for the short-term treatment of digestive diseases in which stomach acid and bile flows back and irritates the food-pipe.  Gastriwin is also used for the management of inflammation and irritation of the food pipe, to treat overproduction of stomach acid and to prevent stomach ulcers caused by the use of certain medicines (NSAIDs)

The following side-effects may commonly occur when using Gastriwin Tablet: 

Abnormal tissue growth on stomach’s lining, diarrhoea, dizziness, gas formation, headache, nausea, pain in the joints, stomach pain, vomiting.

 

INDERAL:  INDERAL® XL is a beta adrenergic blocker indicated for the treatment of hypertension, to lower blood pressure. 

WARNING: Do not stop taking INDERAL® XL suddenly, as heart attacks and worsening of chest pain have occurred. If your doctor decides you should stop taking INDERAL® XL, you may be instructed to slowly reduce your dose over a period of time before stopping it completely.

Antidepressants The hypotensive effects of MAO inhibitors or tricyclic antidepressants may be exacerbated when administered with beta-blockers by interfering with the beta blocking activity of propranolol.

ADVERSE REACTIONS The following adverse events were observed and have been reported in patients using propranolol….

Gastrointestinal: Nausea, vomiting, epigastric distress, abdominal cramping, diarrhoea, constipation, mesenteric arterial thrombosis, ischemic colitis.

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